AFA PEEL is the only peel that does not make you sun sensitive.

AFAs amino acid skin care

AFAs amino acid skin care




What are AFAs?
7 Unique Advantages
Moisture Retention
Effective Exfoliants
Photo Pigmentation
AFAs vs. AHAs
Non Photo-sensitizing
AFAs Program
AFAs Fact

What are AFAs?


AFAs are a new, unique, and fully patented (U.S. Patent #6197317 and 6703030) Cosmeceutical. In fact, AFAs, we believe, are the first cosmeceutical to be patented in this millennium. AFAs are based on the same natural acidic amino acids that serve to retain moisture in human skin. They are also potent antioxidants an extremely helpful against photo pigmentation. They are remarkably free of irritation at effective pH levels.


AFAs are the first cosmeceutical ever to utilize these valuable acidic amino acids as part of a skin care regimen. Independent Board Certified Dermatologists and Plastic Surgeons have clinically tested AFAs for over three years and there have been no adverse incidences reported as a result of their use.


"AFA' is an acronym for Amino acid Filaggrin based Antioxidants. Filaggrin is a protein that occurs in the upper layer of the skin, the responsible for the skin's ability to retain moisture. They are also the same amino acids used to produce AFAs.

AFAs Have 7 Unique Advantages as Topical Anti-Aging Cosmeceuticals:


1. AFAs promote greater moisture retention in human skin
2. AFAs have 3 fold greater antioxidant potency than AHAs
3. AFAs are very effective exfoliants
4. Patients notice visible improvement quickly (often within a few days)
5. AFAs are more powerful against photo-pigmentation
6. AFAs have little irritation when compared to AHAs
7. AFAs are not photosensitizing

AFAs Promote Greater Moisture Retention


The naturally occurring acidic amino acids in the skin constitute what is generally described as the "primary moisture retention factor of human skin". In heavily oxidized, sun damaged skin, acidic amino acids are markedly decreased, and Moisture retention is also significantly reduced. An independent, university study described that these acidic amino acids, the same ones that are used in AFA Gels, are capable of penetrating into the stratum granulosum and significantly increasing moisture retention by as much as three fold. This logically accounts for the dramatic increase in moisture retention of the skin and would account for some of the decrease in visible lines seen with the use of the AFA Gels.

AFAs Are Potent Antioxidants


AHAs are generally viewed as exfoliants, although they have some antioxidant qualities due to single carboxyl group that is part of their molecular structure. The carboxyl group has the positively charged hydrogen ion that has the ability to combine with the singlet oxygen that is responsible for the damaging oxidation of the skin. AFAs are Tri-carboxylic's; they have three carboxyl groups rather than the single group of the AHAs, and thus have three fold the anti-oxidant qualities. We feel that this may account for the dramatically enhanced anti-oxidative effects of AFAs compared to other cosmeceuticals.

AFA™ Facts


  • AFAs are amino acid based skin care.
  • AFA is an acronym for amino acid filaggrin-based antioxidants.
  • AFAs are based on the same amino acids that are recognized as an integral part of the natural moisture system of human skin.
  • AFA act as exfoliants and antioxidants with significantly reduced irritation.
  • AFAs supplement the natural moisture system, so patients experience far less dryness.
  • AFAs significantly improve the appearance of fine lines, and skin texture.
  • AFAs provide outstanding results on photo-pigmentation or aged spots.
  • The program includes in office treatments and products for patient home use.
  • Two US patents have been issued based on the uniqueness of the formulas and the powerful antioxidant abilities of the AFAs.
  • AFAs unique formulation allows the peels and products to be used in tandem with other cosmetic procedures, including IPLs and other laser procedures.
  • AFAs are only available in Canada through medical professionals and are sold in over 25 countries.

The AFA Program


The AFA program is a simple and effective antioxidant skin rejuvenation program. Nevertheless, AFA formulations will only be dispensed by dermatologists and plastic surgeons. There are many factors that have to be evaluated when prescribing the anti-oxidant formulation. Coexisting skin conditions such as rosacea, and actinic keratoses, etc. need to be assessed. Also, the evaluation of other products and/ or pharmaceuticals a patient is currently using. Finally, the patient needs careful instruction and monitoring to insure that they use AFAs properly and achieve the maximum benefit from their product.

The simplicity of the program is very important. Too many steps in a program there will result in poor patient compliance, and therefore inadequate results. The AFA program can be as simple as cleansing and using a moisturizer in the morning, then cleansing and using an AFA Gel in the evening. Adding the AFA In-Office Peels on a regular basis can significantly accelerate the benefits and is strongly recommended. Other ancillary products can be added to address specific patient needs.

AFAs Are Not Photo-Sensitizing


No instance of photosensitization has been reported as a result of the use of AFAs. This may be due to the fact that some of the degradation bi-products of acidic amino acids in the skin, such as Urocanic Acid have long been recognized to be "Natural UV filters".

In summary, AFAs represent an entirely new and uniquely effective cosmeceutical. AFAs are represented at the high end of the cosmeceutical market, not necessarily a replacement for the workhorse cosmeceuticals your patients may have been using, but "a step up". With respect to moisture retention, decrease in photo-pigmentation, anti-oxidative effect, immediate results, low irritancy, and patient acceptance, AFAs certainly are a "step up" for your patients.

AFAs Have Little Irritation Compared to AHAs


There is little irritation with the AFA Gels when compared to even neutralized AHAs. This may be due to the effect of the amino group that is retained in the AFA molecule, which might modify the causticity of the AFAs without changing the overall pH of the molecule. The addition of purines to the AFA Gels also serves to attenuate any potential irritation or causticity.

AFAs Are More Effective At Improving Photo Pigmentation


Clinical reports back to RGR PHARMA have been very positive as far as AFAs improving photo-pigmentation. In many cases, physicians have reported superior results to what they have seen with prescription hydroquinone formulations. As stated above, this is perhaps due to the combined effects of anti-oxidation and exfoliation. It has also been theorized that because AFAs are far less irritating, patients are able to tolerate higher, more effective strengths than they would be able to with AHAs.

AFAs Are Effective Exfoliants


AFAs are very effective exfoliants because they are able to combine a low pH with a small molecular size. The pH of our AFA Gels is below 2.0 and the molecular weight of AFAs under 100. This is a small enough molecule to penetrate into the skin and a low enough pH to be an effective kerolytic.



The Visible Effects of AFAs Occur Quickly


It is not unusual to hear someone say, "Patients have no patience". Patients want quick, if not immediate, results. AFAs offer exactly that to your patients. Patients will often notice an improvement in their skin within the first few days to a week. This is likely due to the immediate increase in moisture retention of the skin. This immediate improvement helps motivate the patient to stick with the program long enough to address more significant issues like photo pigmentation. Clinical reports indicate that photo pigmentation also improves more quickly than with other cosmeceuticals, perhaps due to the combined effect of potent anti-oxidation and exfoliation.


































AFAs Facts

The AFA program

The in-office AFA antioxidant facial

AFA antioxidant facial peels are performed only in a physician's office by trained personnel. AFA facial peels consist of higher concentrations of AFAs, and are done on a weekly or biweekly basis. They will dramatically accelerate the effectiveness of your AFA program.


We recommend that you have at lease six AFA facial peels at weekly or biweekly intervals. Since most patients experience rapid improvement in their skin after their AFA facial, many choose to continue their facials on an ongoing basis as a part of their skin care regimen.


To address your skin's specific issues, your physician or skin care specialist will help you decide whether more than six peels are necessary, and what AFA facial peel strength are required.
The daily home program

An AFA gel appropriate for your skin type will be recommended by your physician or skin care professional, usually beginning with the Milk Gel formulation. The gel is the foundation of your AFA program and should be applied every night.


Evening regimen

Cleanse your face with a mild cleanser (the AFA Cleanser is ideal). Be sure to remove all makeup. Rinse and pat dry (do not rub). Only about three pumps of the Gel are needed for the entire facial application. Spread evenly. Do not apply anything else over the Gel at night.


Morning Regimen

Cleanse your face (again, the AFA Cleanser is ideal), apply an appropriate moisturizer (the AFA Moisturizers as well as a sunscreen are recommended). Once the moisturizer and sunscreen are dry, you may apply make-up, if desired.


AFAs Products


AFA Clay-Peel™:

Find out our new AFA Clay-Peel™


AFA Clay-Peel



AFA Gels:

The AFA Gels are the foundation of your skin care program. Typically you will begin with the Gel Mild, and progress up in strength to the Gel Plus, and then to the Gel Max as your skin adjusts to the AFA Program.


AFA Cleanser:

The Cleanser is gentle, hypo-allergenic and non-comedogenic, yet effectively removes the most stubborn make-up residue. The Cleanser has been designed especially to enhance the effectiveness of the AFA Program.


AFA Moisturizer:

The Consistency of the moisturizer is as elegant as any designer cosmetic, yet free of potentially problematic fragrances and coloring. It is very concentrated and designed to be used sparingly.


AFA Oil-Free Moisturizer:

The Oil-Free Moisturizer provides light but effective moisturization. This elegant and easy to use product is perfect for oily to normal skin.


AFAs Products

See The Difference


The Dramatic results reducing visible photopigmentation that occur with AFAs are demonstrated by the before and after pictures of this patient. The top two pictures use normal lens photography and the bottom two pictures use ultraviolet lens photography.


AFAs difference

Pictures depict 5 months of daily usage of AFA gels

Featured in Dermatology Times, August 1999

Photographs courtesy of Joel Schlessinger, M.D.